
"Casual" way of use I found that won't require knowledge of exactly what's in the encounter deck is when you are already engaging, and you want to use 1 of your 3 actions to get 2~3 more cards without taking any AoO in order to get some event or skill card solutions. Unless encounter deck has 0 enemy, I think it is likely you can pick a 1/1 enemy so you can draw 2 cards to help with the current, more difficult fight, then deal with that thing the next round. You can also look at discard pile too.
An example of in-box combos, cards like Robert Castaigne (4) require materials on hand to go ham with his and "Where's the party?" draws might be just the right thing. If you are with Dakota Garofalo instead, maybe you can get her stat boosts on along with using the draws. Drawing into Bum's Rush or Elusive isn't bad either if you are looking for a way out in the first place, because either you or the enemy is then displaced to balance out the fact that you just increased amount enemy on board.