
This has an interesting use case for investigators. The majority of the time any would likely remove the threat from the board instead of evading it. There are already quite the number of limitations to this card. But even if the targets in a particular scenario are plentiful, you need a reason that you would want the humanoid permanently evaded rather than disposed of.
There are plenty of cultists that accumulate doom, but they are usually easy enough to remove from the board except for maybe Brotherhood Cultist. That makes dealing with him much easier. I think that the real use case for handcuffs would be in multiplayer formats or scenarios where the deck shuffles itself from the discard pile often. If are placing handcuffs on the enemy, then they will remain in play and never get shuffled back in. So you will only see that threat once. While not as good as adding it to the victory display, this can still be helpful for some of those pesky humanoids you might hate seeing such as Seeker of Carcosa.
Even non-fighting splashes for a card would likely have many other options to consider over this one.