Immortal Zoey

Zoey has lots of charges to feed the 2 spectral shields placed on herself.

Ideal state: having 2 bangle of jinxes equipped thanks to Relic Hunter makes it so that whenever an enemy attacks you you replenish 2 charges, which may then be used to cancel 2 damage/horror meant for your investigator card.

Result: You completely ignore enemies that deal less than 2 combined damage/horror.

If you move (or do anything, really) while having a 1 dmg enemy equipped, they provide attacks of opportunity which recharges your bangles by more than necessary and lets you get +2 bonuses against enemies that really need it. You don't even need to kill most enemies, just drag them along.

String of curses is your emergency button in case you really need to kill that cultist with 3 doom on it. Dynamite blast is your emergency button in case the scenario is about to end and you want to do the funniest thing.

You can use brand of Cthugha and Runic axe for additional emergency charges, example if you need to take dmg from a treachery. Also your axe recharges once per round.

Guard dog/heroic rescue/Counterpunch (2) are there for free damage while cancelling attacks.

Economy-wise, Zoey is already rich enough to play the entire deck after engaging one or two enemies, the guard dog helps. If you need cards just do the "draw card" action while being engaged with 4 enemies it's fine.